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Signorini, Alessandro
Institutional profile
Since September 2008, Signorini has been Assistant Professor of Marketing at JCU and he was granted tenure in 2012. He was Chair of the Business Administration Department from 2012-2014 and 2016-2018. Between November 2007 and 2014 he taught as Associate Adjunct Professor for the MBA program at St. John’s University. Since 2005, Prof. Signorini has also cooperated in fundraising projects for a number of non-profit organizations, primarily, Bioversity International, the World Food Programme, Oxfam, and Ashoka. In 2016, Prof. Signorini co-founded an innovative social start-up in the field of charity cashback called Donapp, where he was Chief Marketing Officer until April 2019. In 2016, he was also appointed as a member of the Board of Trustees of Soleterre Foundation, which deals with pediatric oncology. At the moment, Professor Signorini works as senior corporate fundraiser for UniCamillus, a fully-recognized medical university based in Rome.
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Publication Metadata only Marketing sustainable financial products to specific target segments: the case of the Italian market(2019) Signorini, Alessandro; Torosantucci, GaetanaOriginality of the study. Sustainability is generally classified as the balance between economic, social, and environmental factors in the decision making of an organization (Ralph and Strubbs, 2014). In order to fill the criteria of sustainability, the organizational decisions must constantly try to ensure economic stability and growth in the long term, strive to social equity, and preserve the natural environment for the future generations (UNESCO, 2011). This article focuses on one specific aspect of sustainability, sustainable banking, that can be defined as the attempt from commercial and investment banks to include sustainability and social responsibility factors in their operations. In particular, the emphasis is on the offer of banking and financial products and services that have social and environmental sustainable elements along with economic stability and profitability (Boitan, 2015). The inclusion of sustainable elements can be based on a voluntary and independent initiative that banks implement in order to better match the needs of their consumers. Alternatively, banks can adhere to established sustainability frameworks that offer guidelines on how banking and financial products can incorporate sustainable factors (Boitan, 2015). The three most common and well-known frameworks are the Equator Principles, the United Nations Global Compact, and the United Nations Environment Program Financial Initiative (http://www.equator-principles.com, www.unglobalcompact.org, www.unepfi.org).Publication Open Access Applications to augment patient care for Internal Medicine specialists: a position paper from the EFIM working group on telemedicine, innovative technologies & digital health(2024) Pietrantonio, Filomena; Florczak, Michał; Kuhn, Sebastian; Kärberg, Kati; Leung, Tiffany I.; Said Criado, Ismael; Sikorski, S.; Ruggeri, Matteo; Signorini, Alessandro; Rosiello, Francesco; Drago, Carlo; Vinci, Antonio; Barreto, Vasco; Montano, Nicola; Dicker, D.; Gomez Huelgas, RicardoTelemedicine applications present virtually limitless prospects for innovating and enhancing established and new models of patient care in the field of Internal Medicine. Although there is a wide range of innovative technological solutions in Europe, there are overarching elements associated with such technologies when applied to the practices of Internal Medicine specialists. The European Federation of Internal Medicine (EFIM) strongly advocates for active leadership and influence from the Internal Medicine societies and specialist physicians across Europe in the development and application of telemedicine and digital technologies in healthcare. This position paper’s conclusions were drawn via Delphi method, which was developed collaboratively from July 2021 to December 2023. The panel, consisting of experts in clinical medicine, public health, health economics and statistics, assessed various aspects related to telemedicine. Participants assigned scores on a Likert scale reflecting perceived value and potential risks. The findings were consolidated in a comprehensive checklist aligning with relevant literature and a SWOT analysis. Specifically, key issues that need to be addressed include promoting the professional development of e-health competencies in the healthcare and medical workforce, using educational campaigns to promote digital literacy among patients and caregivers, designing and implementing telemedicine applications tailored to local conditions and needs and considering the ethical and legal contexts under which these applications are employed. Importantly, there is currently no consensus on care models or standardized protocols among European Internal Medicine specialists regarding the utilization of telemedicine. This position paper aims to outline the opportunities and challenges associated with the application of telemedicine in Internal Medical practice in Europe.Publication Open Access Women’s Leadership in the Healthcare Landscape. Original Evidence from an Innovative Narrative Review of the Literature: The Female-Led Study(2025) Pietrantonio, Filomena; Mochi, Giorgia; Ricci, Lidia; Simonelli, Maria Sofia; Boschero, Lucilla; D'Alessandro, Biagio; Buno, Francesca; Pieragostini, Luisa; Migliano, Emilia; Russo, Giovanna; Vassallo, Gabriele Angelo; Materazzo, Marco; Granvillano, Giuseppa; Vinci, Antonio; Signorini, Alessandro; Rosiello, FrancescoThe “great man” theory inherently excludes women as it traditionally focuses on leadership features associated with men. In recent years, the healthcare sector has experienced a growing presence of women in leadership roles; however, although female health workers significantly outnumber men, the number of women leaders remains lower than that of men. This article seeks to investigate potential differences between male and female leadership, identify the winning characteristics of female leadership, and examine the barriers and obstacles that may preclude women’s access to leadership positions. A review of existing reviews available on PubMed was conducted using specific search queries. The authors analyzed the selected articles according to specific inclusion and exclusion criteria, using the PICO methodology. Out of 967 articles, 18 met the inclusion criteria. The most frequently identified characteristics of female leadership included a democratic and non-individualistic style, strong communication skills, and empathy. The most common obstacles to the advancement of female leadership included lower compensation, persistent stereotypes and prejudices, and insufficient support from institutions in addressing the gender gap. Academic studies confirm that women tend to adopt a transformational leadership style, in contrast to the more autocratic and assertive male leadership. Further research on female leadership is essential for monitoring progress and fostering actions that allow women to thrive in top leadership positions.Publication Open Access Evaluating Wireless Vital Parameter Continuous Monitoring for Critically Ill Patients Hospitalized in Internal Medicine Units: A Pilot Randomized Controlled Trial(2025) Pietrantonio, Filomena; Signorini, Alessandro; Bussi, Anna Rosa; Rosiello, Francesco; Vinci, Fabio; Delli Castelli, Michela; Pascucci, Matteo; Alessi, Elena; Moriconi, Luca; Vinci, Antonio; Moriconi, Andrea; D'Amico, RobertoBackground: Wireless Vital Parameter Continuous Monitoring (WVPCM) allows the continuous tracking of patient physiological parameters, facilitating the earlier detection of clinical deterioration, especially in low-intensity care settings. The aim of this study is to evaluate the effectiveness of using WVPCM compared to the usual monitoring of critically ill patients hospitalized in Internal Medicine wards. An investigation of the attitude of health professionals towards the use of new technologies in daily practice to improve patient management was also carried out. Methods: The LIght Monitor Study (LIMS) is a prospective, open-label, randomized, multi-center pilot trial comparing WVPCM and conventional nurse monitoring during the first 72 h of hospitalization. A central randomization unit used computer-generated tables to allocate patients to two different types of monitoring. The main outcome was the occurrence of major complications. The study planned to enroll 296 critically ill patients with a Modified Early Warning Score (MEWS) ≥ 3 and/or National Early Warning Score (NEWS) ≥ 5 across two Internal Medicine (IM) Units in Italy. The investigation of the attitude of nurses towards the use of WVPCM was carried out by using a questionnaire and a qualitative survey. Results: Due to the COVID-19 outbreak, the study was interrupted early and only 135 patients (WVPCM = 68; standard care = 67) were randomized. One patient in the control group was excluded from analysis because of drop-out, leaving 134 patients for intention to treat analysis. No statistically significant differences between standard care and WVPCM were observed in terms of major complications (37.5%, vs. 31.2% p = 0.475), in-hospital mortality (17.5% vs. 11.1%, p = 0.309), and median hospital length of stay (9 vs. 10 days, p = 0.463). WVPCM decreased nursing workload compared to the control, as the average time spent by nurses on the detection of vital signs per patient was 0 min per patient per day compared to 24.4 min (p < 0.001) observed in the control group. Twenty-two percent of patients in the WVPCM group (15/68) experienced discomfort with the device, resulting in its removal. The investigation of nurses involved 16 out of 18 people participating in the study. Opinions on the wireless device for patient monitoring were particularly favorable; most of them considered remote monitoring clearly superior to traditional in-person visits and easy to use after a brief practice period. All participants recognized the safety benefits of the system. Conclusions: The reduced sample size of this pilot study does not allow us to draw any conclusions on the superiority of WVPCM compared to standard care in terms of clinical outcomes. However, we observed a positive trend in the reduction of major complications.Publication Open Access Advancing Toward P6 Medicine: Recommendations for Integrating Artificial Intelligence in Internal Medicine(2025) Said-Criado, Ismael; Pietrantonio, Filomena; Montagna, Marco; Rosiello, Francesco; Missikoff, Oleg; Drago, Carlo; Leung, Tiffany I.; Vinci, Antonio; Signorini, Alessandro; Gómez-Huelgas, RicardoBackground: Internists formulate diagnostic hypotheses and personalized treatment plans by integrating data from a comprehensive clinical interview, reviewing a patient’s medical history, physical examination and findings from complementary tests. The patient treatment life cycle generates a significant volume of data points that can offer valuable insights to improve patient care by guiding clinical decision-making. Artificial Intelligence (AI) and, in particular, Generative AI (GAI), are promising tools in this regard, particularly after the introduction of Large Language Models. The European Federation of Internal Medicine (EFIM) recognizes the transformative impact of AI in leveraging clinical data and advancing the field of internal medicine. This position paper from the EFIM explores how AI can be applied to achieve the goals of P6 Medicine principles in internal medicine. P6 Medicine is an advanced healthcare model that extends the concept of Personalized Medicine toward a holistic, predictive, patient-centered approach that also integrates psycho-cognitive and socially responsible dimensions. An additional concept introduced is that of Digital Therapies (DTx), software applications designed to prevent and manage diseases and disorders through AI, which are used in the clinical setting if validated by rigorous research studies. Methods: The literature examining the relationship between AI and Internal Medicine was investigated through a bibliometric analysis. The themes identified in the literature review were further examined through the Delphi method. Thirty international AI and Internal Medicine experts constituted the Delphi panel. Results: Delphi results were summarized in a SWOT Analysis. The evidence is that through extensive data analysis, diagnostic capacity, drug development and patient tracking are increased. Conclusions: The panel unanimously considered AI in Internal Medicine as an opportunity, achieving a complete consensus on the matter. AI-driven solutions, including clinical applications of GAI and DTx, hold the potential to strongly change internal medicine by streamlining workflows, enhancing patient care and generating valuable data.Publication Open Access Age diversity management in healthcare: leveraging generational differences with an inclusive approach(2025) Pietrantonio, Filomena; Brunelli, Giulia; Vassallo, Gabriele Angelo; Moriconi, Luca; Signorini, Alessandro; Moriconi, AndreaThis paper examines the growing generational diversity within the healthcare workforce and highlights the importance of leveraging these differences through an inclusive approach. As Baby Boomers, Generation X, and Millennials coexist in the healthcare workforce, organizations face new challenges and opportunities. Each generation brings its own distinct values, expectations, and work attitudes that significantly impact team dynamics, stress management, job retention, and leadership preferences. Through a comprehensive literature review, the study suggests effective strategies to address generational differences to promote collaboration and team cohesion. Particular attention is paid to the role of coordinators in identifying and applying tailored interventions, such as mentoring, reverse mentoring, shared leadership models, and tailored communication styles, that cater to the specific needs of each generation. The paper emphasizes the relevance of recognizing age-related diversity as an asset to create resilient, adaptable, and high-performing teams. By adopting age diversity management practices, healthcare organizations can better appreciate individual contributions and encourage an environment of mutual respect and learning. Ultimately, the study states that inclusive and flexible leadership can improve staff satisfaction and the quality of patient care in a rapidly evolving healthcare landscape.Publication Open Access Gender Equality in Healthcare Leadership: A Narrative Review of the Literature(2025) Pietrantonio, Filomena; Mochi, Giorgia; Ricci, Lidia; Simonelli, Maria Sofia; Boschero, Lucilla; D'Alessandro, Biagio; Bruno, Francesca; Pieragostini, Luisa; Migliano, Emilia; Russo, Giovanna; Vassallo, Gabriele Angelo; Signorini, Alessandro; Materazzo, Marco; Granvillano, Giuseppa; Vinci, Antonio; Rosiello, FrancescoThe “great man” theory excludes women by definition. Recently, in healthcare, there has been an increasing number of women in leadership positions; however, the number of women leaders is lower than that of men leaders, even though the number of female health workers is far greater than that of men. This article aims to investigate whether there is a difference between male and female leadership, the winning characteristics of the latter and whether (and possibly what) barriers and ob-stacles there are to female leadership. Method: a review of reviews available on Pub-med was conducted using a specific search query. The authors analyzed the articles according to specific inclusion and exclusion criteria, using the PICO methodology. Results: of 967 articles, 18 met the inclusion criteria. Among the typical characteristics of female leadership, the most common are: democratic and non-individualistic style, communication skills and empathy. Among the most common obstacles to the affir-mation of female leadership are lower compensation, the presence of prejudices due to stereotypes and the lack of support from institutions in solving the gender gap. Con-clusions. Academic studies confirm that women tend to apply a transformational leadership in contrast to the autocratic and assertive male leadership. Continued re-search into female leadership is essential for monitoring progress and fostering actions that allow women to prosper in top leadership positions.Publication Open Access Model for estimating the healthcare costs and capacity of intensive care units in Italy in the treatment of patients with COVID-19: remdesivir impact assessment(2020) Ruggeri, Matteo; Signorini, Alessandro; Drago, Carlo; Rosiello, Francesco; Marchetti, MarcoIntroduction: Coronavirus disease 2019 (COVID-19) is caused by a severe acute respiratory syndrome coronavirus 2, which is a human coronavirus responsible for a pandemic. Direct interventions, i.e. physical distancing and use of protective devices, can prevent or limit contagions, however, it is also required to evaluate the optimization of limited resources, such as the Intensive Care Unit (ICU). For this purpose, it is relevant to estimate the impact of therapeutic solutions that reduce the probability that the patient transits to ICU in symptomatic subjects and in need of hospitalization. The therapeutic solutions allow a more rapid recovery of the patient and save scarce resources that can be used in the treatment of other patients. Methods: A forecasting model is designed to estimate the impact of one therapeutic solution, i.e. the antiretroviral Remdesivir, on both the capacity of intensive care and the healthcare costs for hospitals when managing the current emergency. A base case is presented as well as a best and a worst case scenario deriving from the sensitivity analyses. Results: The introduction of Remdesivir in patients receiving low-flow oxygen therapy with the purpose of reducing ICU accesses and deaths leads to 431 million euros cost savings and avoids 17,150 hospitalizations in intensive care and 6,923 deaths. In the best case, 294 million euros savings are estimated, whilst in the worst case the model estimates a saving of 512 million euros. Conclusions: Remdesivir has the potential to reduce the negative effects of the Coronavirus disease, improving patient conditions and reducing death tolls, and can also save scarce healthcare resources during this pandemic, resulting in a shorter hospital stay and fewer ICU admissions. (Market Access)Publication Open Access A cost-effectiveness analysis of Navina Smart on adult patients affected by neurogenic bowel dysfunction(2024) Ruggeri, Matteo; Signorini, Alessandro; Caravaggio, Silvia; Righi, GabrieleBackground and Objectives:The objective of this study is to evaluate the economic impact of the device Navina Smart on patients affected by neurogenic bowel dysfunction and dependent on transanal irrigation within the Italian context. This study employs the perspective of the Italian National Health Service. Methods: The analysis was conducted through a Markov model, comparing two scenarios: standard bowel care vs. transanal irrigation. The model operates on a 30-year time period. The results were reported in terms of net monetary benefit. Results: Transanal irrigation therapy was dominant in all scenarios with lower costs and higher effectiveness. The population was assumed to be composed of 1,000 subjects. Setting the willingness to pay at €35,000.00/QALYs (quality-adjusted life years), the analysis yielded a net monetary benefit of €81,087 and cost savings of €66,101 per patient over 30 years. Conclusion: The results of this study substantiate that transanal irrigation therapy treatment employing the Navina Smart device can significantly benefit patients suffering from neurogenic bowel dysfunction by relieving their symptoms. In addition, this therapy offers important cost savings for the Italian National Health Service by reducing resource utilization.Publication Open Access Intra and Extra Hospitalization Monitoring of Vital Signs. Two Sides of the Same Coin: Perspectives from LIMS and Greenline-HT Study Operators(2023) Pietrantonio, Filomena; Vinci, Antonio; Maurici, Massimo; Ciarambino, Tiziana; Galli, Barbara; Signorini, Alessandro; La Fazia, Vincenzo Mirco; Rosselli, Francescantonio; Fortunato, Luca; Iodice, Rosa; Materazzo, Marco; Ciuca, Alessandro; Cicerchia, Lamberto Carlo Maria; Ruggeri, Matteo; Manfellotto, Dario; Rosiello, Francesco; Moriconi, AndreaBackground: In recent years, due to the epidemiological transition, the burden of very complex patients in hospital wards has increased. Telemedicine usage appears to be a potential high-impact factor in helping with patient management, allowing hospital personnel to assess conditions in out-of-hospital scenarios. Methods: To investigate the management of chronic patients during both hospitalization for disease and discharge, randomized studies (LIMS and Greenline-HT) are ongoing in the Internal Medicine Unit at ASL Roma 6 Castelli Hospital. The study endpoints are clinical outcomes (from a patient’s perspective). In this perspective paper, the main findings of these studies, from the operators’ point of view, are reported. Operator opinions were collected from structured and unstructured surveys conducted among the staff involved, and their main themes are reported in a narrative manner. Results: Telemonitoring appears to be linked to a reduction in side-events and side-effects, which represent some of most commons risk factors for re-hospitalization and for delayed discharge during hospitalization. The main perceived advantages are increased patient safety and the quick response in case of emergency. The main disadvantages are believed to be related to low patient compliance and an infrastructural lack of optimization. Conclusions: The evidence of wireless monitoring studies, combined with the analysis of activity data, suggests the need for a model of patient management that envisages an increase in the territory of structures capable of offering patients subacute care (the possibility of antibiotic treatments, blood transfusions, infusion support, and pain therapy) for the timely management of chronic patients in the terminal phase, for which treatment in acute wards must be guaranteed only for a limited time for the management of the acute phase of their diseases.