Signorini, Alessandro
Loading...
Institutional profile
Since September 2008, Signorini has been Assistant Professor of Marketing at JCU and he was granted tenure in 2012. He was Chair of the Business Administration Department from 2012-2014 and 2016-2018. Between November 2007 and 2014 he taught as Associate Adjunct Professor for the MBA program at St. John’s University. Since 2005, Prof. Signorini has also cooperated in fundraising projects for a number of non-profit organizations, primarily, Bioversity International, the World Food Programme, Oxfam, and Ashoka. In 2016, Prof. Signorini co-founded an innovative social start-up in the field of charity cashback called Donapp, where he was Chief Marketing Officer until April 2019. In 2016, he was also appointed as a member of the Board of Trustees of Soleterre Foundation, which deals with pediatric oncology. At the moment, Professor Signorini works as senior corporate fundraiser for UniCamillus, a fully-recognized medical university based in Rome.
9 results
Publication Search Results
Now showing 1 - 9 of 9
Publication A cost-effectiveness analysis of Navina Smart on adult patients affected by neurogenic bowel dysfunction(2024) Ruggeri, Matteo; Signorini, Alessandro; Caravaggio, Silvia; Righi, GabrieleBackground and Objectives:The objective of this study is to evaluate the economic impact of the device Navina Smart on patients affected by neurogenic bowel dysfunction and dependent on transanal irrigation within the Italian context. This study employs the perspective of the Italian National Health Service. Methods: The analysis was conducted through a Markov model, comparing two scenarios: standard bowel care vs. transanal irrigation. The model operates on a 30-year time period. The results were reported in terms of net monetary benefit. Results: Transanal irrigation therapy was dominant in all scenarios with lower costs and higher effectiveness. The population was assumed to be composed of 1,000 subjects. Setting the willingness to pay at €35,000.00/QALYs (quality-adjusted life years), the analysis yielded a net monetary benefit of €81,087 and cost savings of €66,101 per patient over 30 years. Conclusion: The results of this study substantiate that transanal irrigation therapy treatment employing the Navina Smart device can significantly benefit patients suffering from neurogenic bowel dysfunction by relieving their symptoms. In addition, this therapy offers important cost savings for the Italian National Health Service by reducing resource utilization.Publication Marketing sustainable financial products to specific target segments: the case of the Italian market(2019) Signorini, Alessandro; Torosantucci, GaetanaOriginality of the study. Sustainability is generally classified as the balance between economic, social, and environmental factors in the decision making of an organization (Ralph and Strubbs, 2014). In order to fill the criteria of sustainability, the organizational decisions must constantly try to ensure economic stability and growth in the long term, strive to social equity, and preserve the natural environment for the future generations (UNESCO, 2011). This article focuses on one specific aspect of sustainability, sustainable banking, that can be defined as the attempt from commercial and investment banks to include sustainability and social responsibility factors in their operations. In particular, the emphasis is on the offer of banking and financial products and services that have social and environmental sustainable elements along with economic stability and profitability (Boitan, 2015). The inclusion of sustainable elements can be based on a voluntary and independent initiative that banks implement in order to better match the needs of their consumers. Alternatively, banks can adhere to established sustainability frameworks that offer guidelines on how banking and financial products can incorporate sustainable factors (Boitan, 2015). The three most common and well-known frameworks are the Equator Principles, the United Nations Global Compact, and the United Nations Environment Program Financial Initiative (http://www.equator-principles.com, www.unglobalcompact.org, www.unepfi.org).Publication Intra and Extra Hospitalization Monitoring of Vital Signs. Two Sides of the Same Coin: Perspectives from LIMS and Greenline-HT Study Operators(2023) Pietrantonio, Filomena; Vinci, Antonio; Maurici, Massimo; Ciarambino, Tiziana; Galli, Barbara; Signorini, Alessandro; La Fazia, Vincenzo Mirco; Rosselli, Francescantonio; Fortunato, Luca; Iodice, Rosa; Materazzo, Marco; Ciuca, Alessandro; Cicerchia, Lamberto Carlo Maria; Ruggeri, Matteo; Manfellotto, Dario; Rosiello, Francesco; Moricon, AndreaBackground: In recent years, due to the epidemiological transition, the burden of very complex patients in hospital wards has increased. Telemedicine usage appears to be a potential high-impact factor in helping with patient management, allowing hospital personnel to assess conditions in out-of-hospital scenarios. Methods: To investigate the management of chronic patients during both hospitalization for disease and discharge, randomized studies (LIMS and Greenline-HT) are ongoing in the Internal Medicine Unit at ASL Roma 6 Castelli Hospital. The study endpoints are clinical outcomes (from a patient’s perspective). In this perspective paper, the main findings of these studies, from the operators’ point of view, are reported. Operator opinions were collected from structured and unstructured surveys conducted among the staff involved, and their main themes are reported in a narrative manner. Results: Telemonitoring appears to be linked to a reduction in side-events and side-effects, which represent some of most commons risk factors for re-hospitalization and for delayed discharge during hospitalization. The main perceived advantages are increased patient safety and the quick response in case of emergency. The main disadvantages are believed to be related to low patient compliance and an infrastructural lack of optimization. Conclusions: The evidence of wireless monitoring studies, combined with the analysis of activity data, suggests the need for a model of patient management that envisages an increase in the territory of structures capable of offering patients subacute care (the possibility of antibiotic treatments, blood transfusions, infusion support, and pain therapy) for the timely management of chronic patients in the terminal phase, for which treatment in acute wards must be guaranteed only for a limited time for the management of the acute phase of their diseases.Publication Applications to augment patient care for Internal Medicine specialists: a position paper from the EFIM working group on telemedicine, innovative technologies & digital health(2024) Pietrantonio, Filomena; Florczak, Michał; Kuhn, Sebastian; Kärberg, Kati; Leung, Tiffany I.; Said Criado, Ismael; Sikorski, S.; Ruggeri, Matteo; Signorini, Alessandro; Rosiello, Francesco; Drago, Carlo; Vinci, Antonio; Barreto, Vasco; Montano, Nicola; Dicker, D.; Gomez Huelgas, RicardoTelemedicine applications present virtually limitless prospects for innovating and enhancing established and new models of patient care in the field of Internal Medicine. Although there is a wide range of innovative technological solutions in Europe, there are overarching elements associated with such technologies when applied to the practices of Internal Medicine specialists. The European Federation of Internal Medicine (EFIM) strongly advocates for active leadership and influence from the Internal Medicine societies and specialist physicians across Europe in the development and application of telemedicine and digital technologies in healthcare. This position paper’s conclusions were drawn via Delphi method, which was developed collaboratively from July 2021 to December 2023. The panel, consisting of experts in clinical medicine, public health, health economics and statistics, assessed various aspects related to telemedicine. Participants assigned scores on a Likert scale reflecting perceived value and potential risks. The findings were consolidated in a comprehensive checklist aligning with relevant literature and a SWOT analysis. Specifically, key issues that need to be addressed include promoting the professional development of e-health competencies in the healthcare and medical workforce, using educational campaigns to promote digital literacy among patients and caregivers, designing and implementing telemedicine applications tailored to local conditions and needs and considering the ethical and legal contexts under which these applications are employed. Importantly, there is currently no consensus on care models or standardized protocols among European Internal Medicine specialists regarding the utilization of telemedicine. This position paper aims to outline the opportunities and challenges associated with the application of telemedicine in Internal Medical practice in Europe.Publication Gender Equality in Healthcare Leadership: A Narrative Review of the Literature(2025) Pietrantonio, Filomena; Mochi, Giorgia; Ricci, Lidia; Simonelli, Maria Sofia; Boschero, Lucilla; D'Alessandro, Biagio; Bruno, Francesca; Pieragostini, Luisa; Migliano, Emilia; Russo, Giovanna; Vassallo, Gabriele Angelo; Signorini, Alessandro; Materazzo, Marco; Granvillano, Giuseppa; Vinci, Antonio; Rosiello, FrancescoThe “great man” theory excludes women by definition. Recently, in healthcare, there has been an increasing number of women in leadership positions; however, the number of women leaders is lower than that of men leaders, even though the number of female health workers is far greater than that of men. This article aims to investigate whether there is a difference between male and female leadership, the winning characteristics of the latter and whether (and possibly what) barriers and ob-stacles there are to female leadership. Method: a review of reviews available on Pub-med was conducted using a specific search query. The authors analyzed the articles according to specific inclusion and exclusion criteria, using the PICO methodology. Results: of 967 articles, 18 met the inclusion criteria. Among the typical characteristics of female leadership, the most common are: democratic and non-individualistic style, communication skills and empathy. Among the most common obstacles to the affir-mation of female leadership are lower compensation, the presence of prejudices due to stereotypes and the lack of support from institutions in solving the gender gap. Con-clusions. Academic studies confirm that women tend to apply a transformational leadership in contrast to the autocratic and assertive male leadership. Continued re-search into female leadership is essential for monitoring progress and fostering actions that allow women to prosper in top leadership positions.Publication Model for estimating the healthcare costs and capacity of intensive care units in Italy in the treatment of patients with COVID-19: remdesivir impact assessment(2020) Ruggeri, Matteo; Signorini, Alessandro; Drago, Carlo; Rosiello, Francesco; Marchetti, MarcoIntroduction: Coronavirus disease 2019 (COVID-19) is caused by a severe acute respiratory syndrome coronavirus 2, which is a human coronavirus responsible for a pandemic. Direct interventions, i.e. physical distancing and use of protective devices, can prevent or limit contagions, however, it is also required to evaluate the optimization of limited resources, such as the Intensive Care Unit (ICU). For this purpose, it is relevant to estimate the impact of therapeutic solutions that reduce the probability that the patient transits to ICU in symptomatic subjects and in need of hospitalization. The therapeutic solutions allow a more rapid recovery of the patient and save scarce resources that can be used in the treatment of other patients. Methods: A forecasting model is designed to estimate the impact of one therapeutic solution, i.e. the antiretroviral Remdesivir, on both the capacity of intensive care and the healthcare costs for hospitals when managing the current emergency. A base case is presented as well as a best and a worst case scenario deriving from the sensitivity analyses. Results: The introduction of Remdesivir in patients receiving low-flow oxygen therapy with the purpose of reducing ICU accesses and deaths leads to 431 million euros cost savings and avoids 17,150 hospitalizations in intensive care and 6,923 deaths. In the best case, 294 million euros savings are estimated, whilst in the worst case the model estimates a saving of 512 million euros. Conclusions: Remdesivir has the potential to reduce the negative effects of the Coronavirus disease, improving patient conditions and reducing death tolls, and can also save scarce healthcare resources during this pandemic, resulting in a shorter hospital stay and fewer ICU admissions. (Market Access)Publication Model for Estimating the Impact of Healthcare Costs in Non-Hospitalized Covid-19 Patients Treated with Remdesivir(2022) Ruggeri, Matteo; Signorini, Alessandro; Caravaggio, Silvia; Falcone, Marco; Di Perri, GiovanniObjectives: In March 2020, the COVID-19 pandemic outbreak caused significant negative changes worldwide. Important investments were suddenly needed in the economic, social, and healthcare fields. This analysis sets out to show the economic impact of the administration of remdesivir in ambulatory patients, who are affected by Covid-19, at high risk for severe progression, and eligible for the antiviral treatment. Methods: The budget impact analysis is based on the assumptions already presented in a study published in 2020 by the same Authors. The analysis was updated with a new simulation of the pandemic curve which included the vaccination plan. Data were collected from official Italian sources and from the academic literature. The Italian National Health Service (NHS) perspective was used in the analysis. Remdesivir treatment was compared in terms of economic costs with the Standard of Care over a period of 20 weeks. Such timeframe was chosen because of the uncertainty of the pandemic evolution and considering that this is the time of a complete pandemic curve. A comparison with other therapeutic solutions was not performed in this analysis as the relative costs were not available at the time of the study. Results: The model estimates that, in 20 weeks, 8,002,015 subjects are infected by Covid-19, with a 0.8% hospitalization rate. Among hospitalized patients, 19.6% could be eligible for remdesivir treatment, for a total number of 3,619 patients, with a 12% market share. Conclusion: The analysis shows that remdesivir therapy is dominant and its use could determine a reduction in hospitalizations and transfers to intensive care units compared to the Standard of Care, with a potential saving of € 50.8 million and a decrease of the number of Covid-19-related deaths between 600 and 1,100.Publication Casirivimab and imdevimab: Cost-effectiveness analysis of the treatment based on monoclonal antibodies on outpatients with Covid-19(2023) Ruggeri, Matteo; Signorini, Alessandro; Caravaggio, SilviaBackground and objectives In 2020, the world was profoundly affected by the spread of SARS-CoV-2, a novel coronavirus first identified in December 2019, that was the causative agent of coronavirus disease 2019 (Covid-19), a severe respiratory disease classified as a pandemic by the World Health Organization (WHO) in March 2020. Covid-19 had a significant negative impact on the healthcare facilities and the economies of many countries. A need for pharmacological treatments for Covid-19 patients rapidly emerged to limit the damage caused by the disease and allow for more efficient management of hospital resources. A possible alternative treatment that has achieved encouraging results on Covid-19 is the use of monoclonal antibodies. This research aims to evaluate the cost-effectiveness of a type of monoclonal antibody, specifically the combination of casirivimab and imdevimab, and assess its impact on the Italian healthcare system. Methods The casirivimab and imdevimab treatment efficacy on outpatients with Covid-19 was tested using a predictive Markov model. Research endpoints include hospitalizations, Intensive Care Unit (ICU) admissions, and deaths. This was translated into terms of benefits (savings) and costs for the Italian National Health Service (NHS). The model operates on a predictive time frame of 20 weeks starting from September 2021 until January 2022. The data used to populate the model comes from international academic studies and open-access resources on online databases. Results The model estimates the effects that can be achieved by administering casirivimab and imdevimab treatment on outpatients with Covid-19. According to the estimates, the treatment can prevent approximately 4,000 hospitalizations, 3,589 ICU admissions, and 1,500 deaths in the considered 20-week period. The potential cost savings amount to EUR 78 million, mainly attributable to the reduction in the number of hospitalizations and access to ICU. More specifically, a difference of EUR 15,4 million can be observed due to the reduction in the number of hospitalizations, a difference of EUR 59,3 million due to the reduction in the number in intensive care, and a difference of EUR 20,3 million due to the reduction in deaths as a consequence of the reduction of hospitalizations. These results are already very significant, considering that in Italy, only 4.76% of the population is eligible for monoclonal antibody treatment. Conclusion The administration of casirivimab and imdevimab in outpatients with Covid-19 can accelerate recovery from the disease for patients, make hospital resource management more efficient and significantly reduce costs for healthcare facilities.Publication Estimation Model for Healthcare Costs and Intensive Care Units Access for Covid-19 Patients and Evaluation of the Effects of Remdesivir in the Portuguese Context: Hypothetical Study(2022) Ruggeri, Matteo; Signorini, Alessandro; Caravaggio, Silvia; Rua, João; Luís, Nuno; Braz, Sandra; Aragão, FilipaBackground and Objectives In March 2020, the World Health Organization announced a state of emergency due to the appearance of a pandemic caused by the Coronavirus 2 (SARS-CoV-2), a severe acute respiratory syndrome, known as Covid-19. Most governments chose to implement precautionary measures, e.g., physical distancing and use of protective devices, which can in part limit the transmission of the virus. However, the healthcare system experienced numerous structural problems in managing the Covid-19 patients given the limited human and technical resources in critical areas, such as the intensive care units (ICUs). Different therapeutic solutions should therefore be assessed, which can potentially minimize the negative impact of the disease on patients, favoring their recovery and optimizing healthcare resources. The objective of this study is to simulate the impact of remdesivir treatment on the pandemic course in the long term. Methods A forecasting model is designed to estimate how remdesivir would impact the ICU capacity and the healthcare costs from the hospital perspective when managing COVID-19 patients. This model is applied in the Portuguese context with a 20-week projection starting on May 1st and concluding on September 18th, 2021. The data inputs were carefully collected by consulting different sources, such as published global literature, official governmental reports, and available infectious diseases databases, i.e., Our World in Data, Portuguese Ministry of Health, and experts’ opinions. Results The model showed that the introduction of remdesivir-based treatment in patients with Covid-19 pneumonia requiring supplemental oxygen therapy generates a significant reduction in both the number of ICU admissions and deaths, which would produce more than €23 million in cost savings and avoid more than 261 ICUs admissions and 166 deaths. Conclusion It is demonstrated that alternative treatments such as remdesivir can reduce both the health burden for healthcare facilities, optimize their management, and improve patients’ clinical conditions. However, the model is centered on Rt values, which cannot be generalized to the entire country; hence, the results of this research should be considered as a “hypothetical study”.